Before I started traveling international I traveled domestically. I visited all of the continental U.S. and believe this area is the second best after the southwest...there's just one hold-up. It can't be seen in a typical week-long vacation. There's lots to see, the distances are far between, and there's not many nearby airports. If you have the time though this is a very rewarding area to travel.
I have a cousin who moved out here - it seems a random place to move but I totally get it